Thanks to its iconic arch, St. Louis has long been referred to as the "Gateway City," the passageway to the American west. Missouri's second largest city is situated just south of the confluence of the Missouri and Mississippi rivers. St. Louis lies at the heart of Greater St. Louis, a metropolitan area of nearly three million people in Missouri and Illinois. The region is known as an academic and corporate center for the biomedical sciences, with St. Louis University and Washington University being the primary research centers. A popular business center, St. Louis is home to some of the country's largest privately held corporations, including Enterprise Rent-A-Car, Graybar, Scottrade, Edward Jones, and also some of the largest public corporations and corporate divisions, including Emerson, Energizer, Anheuser-Busch, Inc., Boeing Integrated Defense Systems, Purina, Express Scripts, Monsanto Company, and Wells Fargo Advisers.

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